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KMID : 0617819960060010219
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Journal of Wonkwang Oriental Medicine
1996 Volume.6 No. 1 p.219 ~ p.229
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Inhibitory Effect of Anaphylaxis by Poncirus trifoliata
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李彦政/Lee, Eon-Jeong
朱泓炫/金炯均/宋峰根/Joo, Hong-Hyun/Kim, Hyeong-Kyun/Song, Bong-Keun
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Abstract
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The effect of water extract of Poncirus trifoliata fruit (ATFE) on compound 48/80 induced anaphylaxis was studied in the rat.
The following results have obtained.
1. Optimal lethal dose of compound 48/80 was 8ug/gm B.W.
2. PTFE was found to exhibit an inhibitory activity on the anaphylaxis induced by compound 48/80.
3. Administration of PTFE 60 min before or 5 min after had a better result than 10 min after anaphylaxis induced by compound 48/80.
4. PTFE also inhibited significantly the serum histamine release in anaphylaxis induced by compound 48/80 in the rat.
5. Administration of PIFE before 30 min decreased PCA reaction induced by anti DNP-IgE and DNP-HSA.
This result indicates that poncirus trifoliata suppresses the anaphylaxis induced by compound 48/80 with decreasing the serum histamine release.
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